解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In the present study, we investigated the role of lysyl oxidase‑like 2 (LOXL2), the correlation between LOXL2 and epithelial to mesenchymal transition (EMT) and the effects of using β‑aminopropionitrile (BAPN) to inhibit LOXL2 with the aim of reducing tumor progression in hepatocellular carcinoma (HCC). The expression...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6349
更新日期:2018-06-01 00:00:00
abstract::Cucurbitacin D (CuD), isolated from plants from the Cucurbitaceae family, is a potential antitumour agent since it inhibits proliferation, migration and metastasis of cancer cells. Despite CuD antitumour activity in cancer cells, the effects of CuD on gastric cancer cell lines remain unclear. The present study aimed t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6361
更新日期:2018-06-01 00:00:00
abstract::Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6369
更新日期:2018-06-01 00:00:00
abstract::Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6367
更新日期:2018-06-01 00:00:00
abstract::Acquired chemoresistance refers to tumor cells gradually losing their sensitivity to anticancer drugs during the course of treatment, resulting in tumor progression or recurrence. This phenomenon, which has deleterious outcomes for the patient, has long been observed in patients with glioblastoma receiving temozolomid...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6322
更新日期:2018-05-01 00:00:00
abstract::Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6262
更新日期:2018-04-01 00:00:00
abstract::We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6269
更新日期:2018-04-01 00:00:00
abstract::Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6283
更新日期:2018-04-01 00:00:00
abstract::Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6246
更新日期:2018-04-01 00:00:00
abstract::Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6242
更新日期:2018-04-01 00:00:00
abstract::The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6208
更新日期:2018-03-01 00:00:00
abstract::Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6189
更新日期:2018-03-01 00:00:00
abstract::Cancer cachexia is a life‑threatening syndrome associated with myofiber damage. Tumor factors impair muscle regeneration by promoting myoblast apoptosis. Ghrelin is a multifunctional hormone with an anti‑apoptotic effect, but its mechanism of action is not fully understood. In the present study, we investigated whethe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6213
更新日期:2018-03-01 00:00:00
abstract::Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6202
更新日期:2018-03-01 00:00:00
abstract::Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) has been recently reported to play a role in tumor progression, drug resistance and tumorigenesis. However, little is known about the effects of NEK2 in hepatocellular carcinoma (HCC) metastasis and the underlying mechanism. NEK2 expression levels were e...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6224
更新日期:2018-03-01 00:00:00
abstract::The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6215
更新日期:2018-03-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is known to have a high malignant potential. Because of its high recurrence rate, ICC has a poor prognosis even after complete tumor resection. Compared with normal differentiated cells, cancer cells have an altered metabolism for supporting their survival in severe conditions. Ca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6172
更新日期:2018-03-01 00:00:00
abstract::Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6155
更新日期:2018-03-01 00:00:00
abstract::The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6145
更新日期:2018-02-01 00:00:00
abstract::The multi-target kinase inhibitor sorafenib has been approved for the treatment of patients with advanced differentiated thyroid cancer. However, different sensitivities to sorafenib have been observed, and few patients have benefited from sorafenib treatment in the long term. In the event of acquired resistance to so...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6118
更新日期:2018-02-01 00:00:00
abstract::B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6136
更新日期:2018-02-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6135
更新日期:2018-02-01 00:00:00
abstract::The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6105
更新日期:2018-01-01 00:00:00
abstract::We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6087
更新日期:2018-01-01 00:00:00
abstract::Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6069
更新日期:2018-01-01 00:00:00
abstract::Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important ro...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6074
更新日期:2018-01-01 00:00:00
abstract::Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reporte...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6030
更新日期:2017-12-01 00:00:00
abstract::Pancreatic cancer is one of the most fatal types of cancer and is associated with a dismal prognosis. Gemcitabine-based chemotherapy is clinically used for the treatment of advanced pancreatic cancer. However, many forms of pancreatic cancer have acquired resistance to gemcitabine. In order to prevent patients from su...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6026
更新日期:2017-12-01 00:00:00
abstract::Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6046
更新日期:2017-12-01 00:00:00
abstract::Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in h...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6043
更新日期:2017-12-01 00:00:00
abstract::Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung cancer and the third leading cause of cancer-related mortality after lung and colon cancer. The etiology of most cases of prostate cancer are not fully known, and therefore it is essential to search for the molecular basis of pros...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2017.5972
更新日期:2017-11-01 00:00:00
abstract::Metastasis is the primary cause of death in lung cancer patients and EMT (epithelial-mesenchymal transition) promotes metastasis. Previous study revealed that DAL-1 (differentially expressed in adenocarcinoma of the lung) could attenuate EMT and metastasis in non-small cell lung cancer (NSCLC). Further study proved th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6000
更新日期:2017-11-01 00:00:00
abstract::Soft tissue sarcomas are rare and aggressive tumors arising from connective tissues. Adjuvant radiotherapy is a commonly used treatment approach for the majority of sarcomas. We attempted to identify a gene signature that can predict radiosensitive patients who are most likely to have a better treatment response from ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5999
更新日期:2017-11-01 00:00:00
abstract::Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5970
更新日期:2017-11-01 00:00:00
abstract::Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer pati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5941
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5937
更新日期:2017-11-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes mediating cell survival, proliferation and angiogenesis and is aberrantly activated in various types of malignancies, including bladder cancer. We examined whether it could be a novel therapeutic target for bladder cancer usin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5902
更新日期:2017-10-01 00:00:00
abstract::While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance of the cancer cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in the development of the Taxol-resistance of breast cancer. We establish...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5908
更新日期:2017-10-01 00:00:00
abstract::The present study demonstrated that chaetocin, a natural small-molecule product produced by Chaetomium fungal species and a potential anticancer agent, inhibited the viability and invasive ability of the human intrahepatic cholangio-carcinoma cell line CCLP-1 in vivo and in vitro as revealed by CCK-8 and Transwell inv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5921
更新日期:2017-10-01 00:00:00
abstract::The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blottin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5862
更新日期:2017-10-01 00:00:00